- Salyer
- Samoa
- San Augustine
- San Benito
- San Gregorio
- San Juan Hot Springs
- San Luis Rey
- San Pasqual
- San Pedro
- San Quentin
- San Simeon
- San Ysidro
- Santa Ana Heights
- Santa Margarita
- Santa Rita Park
- Santa Susana
- Santa Ysabel
- Saranap
- Sargent
- Saticoy
- Saugus
- Sawyers Bar
- Scotia
- Scotland
- Scott Bar
- Searles
- Seiad Valley
- Selby
- Sequoia National Park
- Sespe