- Sedgwick
- Seven Stars
- Shanks Mill
- Shrivers Corners
- Slate Ridge
- Square Corner
- Stremmels
- Saint Clair
- Salida
- Sample
- Sandy Creek
- Schenley Heights
- Shadow Shuttle
- Shadyside
- Shannon Heights
- Sharpe Hill
- Sheraden
- Shields
- Sixmile Island
- Sligo
- Snowden
- Soho
- South Hills
- Spring Hill
- Squirrel Hill
- Stanton Heights
- Stonedale
- Stoops Ferry
- Strip District
- Sturgeon-Noblestown