- Stave Island (historical)
- Salkehatchie
- Sampson Island
- Sawyers Island
- Seabrook
- Settlement Islands
- Sidney
- Smyly
- Sniders Crossroads
- Springtown
- Stokes
- Segars
- Suggs Crossroads
- Syracuse
- Selma
- Sinclair Crossroads
- Squires
- Salisbury Acres
- Scotch Range Estates
- Slandsville
- Southern Palms
- Sprucewood
- Stallsville
- Stratton Capers
- Sugar Hill
- Summerset Acres
- Summerville Farms
- Summerville Place
- Summerwood
- Sweetbriar